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CYP2B6 is A very powerful CYP enzyme involved in the metabolism of S-methadone and to an extent, R-methadone. The expression of CYP2B6Benzodiazepines: May perhaps boost the CNS depressant effect of Methadone. Management: Clinicians should generally keep away from concurrent utilization of methadone and benzodiazepines when achievable; any blended u